"If you have not evacuated yet, you are quickly running out of time," said St. Petersburg Mayor Kenneth T. Welch. The Tampa Bay region, home to more than 3.3 million people, hasn't seen a direct hit from a major hurricane in more than a century. Milton fluctuated between categories 4 and 5 as it approached, but regardless of the distinction in wind speeds, the National Hurricane Center said, it would be a major and extremely dangerous storm when its center makes landfall late Wednesday. “This is it, folks,” said Cathie Perkins, emergency management director in Pinellas County, which sits on the peninsula that forms Tampa Bay. “Those of you who were punched during Hurricane Helene, this is going to be a knockout. You need to get out, and you need to get out now.” The famous Sunshine Skyway Bridge, which spans the mouth of Tampa Bay and whose traffic is susceptible to high winds, closed around midday. Other major bridges were to close, as well, Perkins said. Residents should not feel relief because of indications Milton's center might come ashore south of Tampa, she said. “Everybody in Tampa Bay should assume we are going to be ground zero,” she said. The normally busy interstate leading into downtown Tampa was mostly free of vehicles early Wednesday. Few cars moved on side streets. Drivers hoping to top off tanks were hard-pressed to find stations that weren't closed or boarded up. Many had plastic-wrapped their fuel pumps to keep nozzles from whipping around in hurricane-force winds. Read more: https://www.9news.com/article/weather/hurricane/hurricane-milton-florida/507-5693e7fd-50a9-4593-9ca3-d9a3e1be7848 More local videos here: https://bit.ly/2Pa0d1l Subscribe to NEXT: http://bit.ly/2eP1GwI Stay connected: 9NEWS Website: http://www.9news.com/ Facebook: https://www.facebook.com/ilike9news Twitter: https://twitter.com/9NEWS Instagram: https://www.instagram.com/9newsdenver/ Download the 9NEWS App: https://www.9news.com/appredirect/ Sign up for the 9NEWSLETTER: https://www.9news.com/email 9NEWS (KUSA) is located in Denver, Colorado.